反应详情

To a solution of 1-benzenesulfonyl-7-methoxy-4-nitro-1H-indole (R) (1 eq) in methanol was added a solution of sodium hydroxide (5 eq) in water. The solution was heated to reflux for 3 hrs. Methanol was removed under reduced pressure then water and ethyl acetate were added. The ethyl acetate layer separated and washed repeatedly (3×) with water. The ethyl acetate layer was concentrated and evaporated to dryness to produce the desired product.

1. temperatureThe solution was heated
2. temperatureto reflux for 3 hrs
3. customMethanol was removed under reduced pressure
4. additionwater and ethyl acetate were added
5. customThe ethyl acetate layer separated
6. washwashed repeatedly (3×) with water
7. concentrationThe ethyl acetate layer was concentrated
8. customevaporated to dryness