HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66727284, compound → HCID 66727587, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66727284 | HCID 66727284 | — |
| Reactant | HCID 66727487 | HCID 66727487 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 66727587 | HCID 66727587 | — |
Reaction Steps
The Weinreb amide of 2-methanesulfonyl-6-ethoxy-isonicotinic acid was also converted to (S)-1-(2-methanesulfonyl-6-methoxy-pyridin-4-yl)-ethylamine hydrochloride according to methods described in Example 43 except during the Grignard addition methyl magnesium bromide was added to the Weinreb amide instead of ethyl magnesium chloride to afford the corresponding methyl ketone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063065B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-833702141bd542649d881bb5cfd47426 |
| Source note | uspto-grants-2011_11 |