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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 559721Generated: October 28, 2026

Hydrochloric Acid → 1-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

https://huagongshe.com/reaction/559721

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant1,4-DioxaneHCID 31275—
ReactantHCID 66727644HCID 66727644—
SolventMethanolHCID 887—
Product1-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)HCID 21292272—

Reaction Steps

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063065B2
Source datasetuspto-grants-2011_11
ORD IDord-b684ce20d32b410c84d2b2663417fa28
Source noteuspto-grants-2011_11