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2-Aminothiazole → 1-(4-Chlorophenoxy)-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 4-Chlorophenol | HCID 4684 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(4-Chlorophenoxy)aniline | HCID 76010 | — |
| 生成物 | 1-(4-Chlorophenoxy)-2-nitrobenzene | HCID 3016050 | 71% |
| 生成物 | N-[2-(4-Chlorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732782 | 62% |
反応手順
2-(4-Chlorophenoxy)-1-nitrobenzene (0.88 g, 71%) was prepared from 4-chlorophenol (0.70 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-chlorophenoxy)aniline (0.50 g, 65%) following general procedure B. N-[2-(4-Chlorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (106 mg, 62%) was prepared from 2-(4-chlorophenoxy)aniline (109 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063081B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-e963dd053c0b4bd49d14c1b685e6a232 |
| 出典メモ | uspto-grants-2011_11 |