HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(4-Isopropylphenoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 4-Isopropylphenol | HCID 7465 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-(4-Isopropylphenoxy)aniline | HCID 26189126 | — |
| Product | N-[2-(4-Isopropylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732791 | 70% |
| Product | 2-(4-Isopropylphenoxy)-1-nitrobenzene | HCID 66998970 | 75% |
Reaction Steps
2-(4-Isopropylphenoxy)-1-nitrobenzene (0.95 g, 75%) was prepared from 4-isopropylphenol (0.68 g, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-isopropylphenoxy)aniline (0.34 g, 60%, 2.5 mmol scale) following general procedure B. N-[2-(4-Isopropylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (247 mg, 70%) was prepared from 2-(4-isopropylphenoxy)aniline (227 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2a9e41004e5d42cab1bcc58c7eb1ddb2 |
| Source note | uspto-grants-2011_11 |