Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 반응물 | 1,3-Difluoro-2-nitrobenzene | HCID 87922 | — |
| 반응물 | 2-(2,3-Dimethoxyphenoxy)-6-fluoroaniline | HCID 66998905 | — |
| 촉매 | N-[2-(2,3-Dimethoxyphenoxy)-6-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59732837 | — |
| 생성물 | 2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene | HCID 66999009 | 72% |
반응 단계
2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene (1.05 g, 72%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,6-difluoronitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-6-fluoroaniline (0.66 g, 70%) following the general procedure C N-[2-(2,3-Dimethoxyphenoxy)-6-fluorophenyl]-N′-(thiazol-2-yl)urea (136 mg, 70%) was prepared from 2-(2,3-dimethoxyphenoxy)-6-fluoroaniline (131 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063081B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-64eef1ed768a4dd189346230da30a49b |
| 출처 메모 | uspto-grants-2011_11 |