Methanesulfonyl chloride → HCID 59732999, compound

HRID 559918Notes

Reaction equation

[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=2[C:23]([CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:24])=[O:14])[S:10][CH:11]=1)=[O:4].[CH3:30][S:31](Cl)(=[O:33])=[O:32]>>[CH:25]1([C:23]([C:17]2[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=2[NH:15][C:13](=[O:14])[NH:12][C:9]2[S:10][CH:11]=[C:7]([CH2:6][NH:5][C:3](=[O:4])[CH2:2][NH:1][S:31]([CH3:30])(=[O:33])=[O:32])[N:8]=2)=[O:24])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 86593069HCID 86593069, compound

Product 1

HCID 59732999HCID 59732999, compoundYield 84%

Procedure

N-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-ylmethyl}-2-methanesulfonylamino-acetamide (103 mg, 84%) was prepared from 2-amino-N-{2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-ylmethyl}-acetamide (104 mg, 0.25 mmol) and methanesulfonyl chloride (0.04 mL, 0.5 mmol) following the general procedure L.

Sources & evidence

ORD record: ord-a252b383b1984293a7bcdfcf434445e9
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063081B2

Reaction notes

Loading…