2-(Methylsulfonyl)ethanamine → HCID 59732738, compound

HRID 559923Notes

Reaction equation

HRID 559923 reaction equation
[Cl:1][C:2]1[S:6][C:5]([NH:7][C:8](=[O:27])[NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][C:11]=2[C:20]([CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:21])=[N:4][CH:3]=1.[CH3:28][S:29]([CH2:32][CH2:33][NH2:34])(=[O:31])=[O:30]>>[Cl:1][C:2]1[S:6][C:5]([NH:7][C:8](=[O:27])[NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([NH:34][CH2:33][CH2:32][S:29]([CH3:28])(=[O:31])=[O:30])=[O:19])=[CH:12][C:11]=2[C:20]([CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)=[O:21])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 59732956HCID 59732956, compound

Product 1

HCID 59732738HCID 59732738, compoundYield 70.2%

Procedure

2-{4-[3-(5-Chloro-thiazol-2-yl)-ureido]-3-cyclopentanecarbonyl-phenyl}-N-(2-methanesulfonyl-ethyl)-acetamide (180 mg, 70%) was prepared from {4-[3-(5-chloro-thiazol-2-yl)-ureido]-3-cyclopentanecarbonyl-phenyl}-acetic acid (204 mg, 0.5 mmol) and 2-methanesulfonyl-ethylamine (62 mg, 0.5 mmol) following the general procedure K.

Sources & evidence

ORD record
ord-a7f0275bdf5a49639b9a4c7d5b2912a6
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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