HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic anhydride → HCID 86593073, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | HCID 59732818 | HCID 59732818 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86593073 | HCID 86593073 | 56.2% |
Reaction Steps
1-[4-(amino-ethyl)-thiazol-2-yl]-3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-urea (0.03 g, 0.08 mmol) and succinic anhydride (0.02 g, 0.16 mmol) in 10 mL DCM were refluxed for 2 h. Reaction was concentrated and purified on silica gel using 5% MeOH/EtOAc to yield the pure product (20 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ce330800ae79446986a69fd2198b7bc0 |
| Source note | uspto-grants-2011_11 |