HuagongsheHuagongshe Chemistry Print Report · For research reference only
{4-[3-(5-Bromo-thiazol-2-yl)-ureido]-3-cyclopentanecarbonyl-phenyl)-acetic acid ethyl ester → (3-Cyclopentanecarbonyl-4-{3-[5-(pyridin-2-ylsulfanyl)-thiazol-2-yl]-ureido}-phenyl)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {4-[3-(5-Bromo-thiazol-2-yl)-ureido]-3-cyclopentanecarbonyl-phenyl)-acetic acid ethyl ester | HCID 86593076 | — |
| Reactant | HCID 178418616 | HCID 178418616 | — |
| Product | (3-Cyclopentanecarbonyl-4-{3-[5-(pyridin-2-ylsulfanyl)-thiazol-2-yl]-ureido}-phenyl)-acetic acid ethyl ester | HCID 59732749 | 30% |
Reaction Steps
(3-Cyclopentanecarbonyl-4-{3-[5-(pyridin-2-ylsulfanyl)-thiazol-2-yl]-ureido}-phenyl)-acetic acid ethyl ester (153 mg, 30%) was prepared from {4-[3-(5-bromo-thiazol-2-yl)-ureido]-3-cyclopentanecarbonyl-phenyl}-acetic acid ethyl ester (480 mg, 1 mmol) and 2-mercapto-pyridine (222 mg, 2 mmol) following the general procedure Q.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-5954db95cd174a49aa424ef512a55236 |
| Source note | uspto-grants-2011_11 |