2-Aminothiazole → N-[2-(2-Methoxy-benzoyl)-5-methoxy-phenyl]-N'-(thiazol-2-yl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	2-Amino-4-methoxybenzoic acid	HCID 351010	—
Reactant	(2-Amino-4-methoxy-phenyl)-(2-methoxy-phenyl)-methanone	HCID 66998984	—
Product	N-[2-(2-Methoxy-benzoyl)-5-methoxy-phenyl]-N'-(thiazol-2-yl)urea	HCID 59732994	68%
Product	(2-Amino-4-methoxy-phenyl)-(2-methoxy-phenyl)-methanone	HCID 66998984	28%

Reaction Steps

(2-Amino-4-methoxy-phenyl)-(2-methoxy-phenyl)-methanone (720 mg, 28%) was prepared from 2-amino-4-methoxy-benzoic acid (1.67 g, 0.1 mol) following the general procedure S. N-[2-(2-Methoxy-benzoyl)-5-methoxy-phenyl]-N′-(thiazol-2-yl)urea (131 mg, 68%) was prepared from (2-amino-4-methoxy-phenyl)-(2-methoxy-phenyl)-methanone (129 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063081B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-fedae572b8664854b73ca06b8ac2c072
Source note	uspto-grants-2011_11