HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanol → 3-Propoxy-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanol | HCID 1031 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-propoxyaniline | HCID 24698653 | — |
| Product | 1-(4-Methyl-2-propoxy-phenyl)-3-thiazol-2-yl-urea | HCID 47363896 | 75% |
| Product | 3-Propoxy-4-nitrotoluene | HCID 58255524 | 80% |
Reaction Steps
3-Propoxy-4-nitrotoluene (0.79 g, 80%) was prepared from 1-propanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-propoxyaniline (0.54 g, 82%) following general procedure C. 1-(4-Methyl-2-propoxy-phenyl)-3-thiazol-2-yl-urea (220 mg, 75%) was prepared from 4-methyl-2-propoxyaniline (165 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-1c8c59bb8d754fe49644ef1e6c576a86 |
| Source note | uspto-grants-2011_11 |