1-Butanol → 2-Butoxy-4-methyl-1-nitrobenzene

Participants

Role	Name	HCID	Charge
Reactant	1-Butanol	HCID 263	—
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	Benzene, 2-fluoro-4-methyl-1-nitro-	HCID 67966	—
Reactant	2-Butoxy-4-methylbenzenamine	HCID 24708940	—
Product	2-Butoxy-4-methyl-1-nitrobenzene	HCID 18474285	75%
Product	HCID 59732836	HCID 59732836	70%

Reaction Steps

3-(1-Butoxy)-4-nitrotoluene (0.78 g, 75%) was prepared from 1-butanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(1-butoxy)aniline (0.47 g, 70%) following general procedure C. 1-(2-Butoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (210 mg, 70%) was prepared from 4-methyl-2-(1-butoxy)aniline (179 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063081B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-fd24e7a2d1144cdda37c324fbc7f8dfb
Source note	uspto-grants-2011_11