HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-(2-Methyl-allyloxy)-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Methallyl alcohol | HCID 10557 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-[(2-methylprop-2-en-1-yl)oxy]aniline | HCID 45091245 | — |
| Product | HCID 59733018 | HCID 59733018 | 70% |
| Product | 3-(2-Methyl-allyloxy)-4-nitrotoluene | HCID 60357844 | 75% |
Reaction Steps
3-(2-Methyl-allyloxy)-4-nitrotoluene (0.78 g, 75%) was prepared from methallyl alcohol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(2-methyl-allyloxy)aniline (0.47 g, 70%) following general procedure B. 1-[4-Methyl-2-(2-methyl-allyloxy)-phenyl]-3-thiazol-2-yl-urea (210 mg, 70%) was prepared from 4-methyl-2-(2-methyl-allyloxy)aniline (179 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-bd8760d32a9945bdbdfea53e8eec5e4a |
| Source note | uspto-grants-2011_11 |