HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-Cyclopentylmethoxy-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | Cyclopentanemethanol | HCID 77195 | — |
| Reactant | 2-(Cyclopentylmethoxy)-4-methylaniline | HCID 26189518 | — |
| Product | 1-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732830 | 68% |
| Product | 3-Cyclopentylmethoxy-4-nitrotoluene | HCID 66998981 | 70% |
Reaction Steps
3-Cyclopentylmethoxy-4-nitrotoluene (0.82 g, 70%) was prepared from cyclopentylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 2-cyclopentylmethoxy-4-methyl-aniline (0.58 g, 81%) following general procedure C. 1-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (225 mg, 68%) was prepared from 2-cyclopentylmethoxy-4-methyl-aniline (205 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-26c87cad44fa491ea6b885cbc4ebb6fb |
| Source note | uspto-grants-2011_11 |