Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | Isobutanol | HCID 6560 | — |
| 반응물 | 1,4-Difluoro-2-methyl-5-nitrobenzene | HCID 230658 | — |
| 반응물 | 5-Fluoro-4-methyl-2-(2-methylpropoxy)aniline | HCID 45091606 | — |
| 생성물 | 1-(5-Fluoro-2-isobutoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732736 | 64% |
| 생성물 | 2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene | HCID 66999163 | 65% |
반응 단계
2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene (0.73 g, 65%) was prepared from 2-methylpropanol (0.46 ml, 5.0 mmol) and 2,5-difluoro-4-nitrotoluene (0.86 g, 5.0 mmol) following the general procedure G. This was reduced to 5-fluoro-4-methyl-2-(2-methylpropoxy)-aniline (0.45 g, 70%) following general procedure C. 1-(5-Fluoro-2-isobutoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (205 mg, 64%) was prepared from 5-fluoro-4-methyl-2-(2-methylpropoxy)-aniline (197 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063081B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-4e05f1ae2931468a838910fe4fd874e2 |
| 출처 메모 | uspto-grants-2011_11 |