HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| Reactant | 4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998878 | — |
| Reactant | 2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-aniline | HCID 66999002 | — |
| Product | 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea | HCID 59732805 | 65% |
| Product | 3-(2-Fluoro-6-methoxyphenoxy)-nitrotoluene | HCID 66999033 | 65% |
Reaction Steps
3-(2-fluoro-6-methoxyphenoxy)-nitrotoluene (0.9 g; 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure A. This compound was reduced to 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.58 g, 72%) following the general procedure C. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea (122 mg, 65%) was prepared from 2-(2-fluoro-6-methoxy-phenoxy)-4-methyl-aniline (124 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063081B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-71a532d1965946ffaa55861fbfd89cca |
| Source note | uspto-grants-2011_11 |