Morpholine → HCID 59733004, compound

HRID 560023Notes

Reaction equation

HRID 560023 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]=O)=[CH:7][C:6]=1[NH:13][C:14]([NH:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1)=[O:15].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[CH:7][C:6]=1[NH:13][C:14]([NH:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1)=[O:15]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 597329541-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea

Product 1

HCID 59733004HCID 59733004, compoundYield 78%

Procedure

1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-morpholin-4-ylmethyl-phenyl]-3-thiazol-2-yl-urea (35 mg, 78%) was prepared from 1-[2-(2-fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea (39 mg, 0.1 mmol) and morpholine following the general procedure O.

Sources & evidence

ORD record
ord-32be4e4f51784a3c8c6e4898931b63ab
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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