(2-Amino-5-methyl-phenyl)-cyclopropyl-methanone → (2-Amino-5-methyl-phenyl)-cyclobutyl-methanone

HRID 560032Notes

Reaction equation

HRID 560032 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][CH2:12]1)=[O:10].[CH3:14]ON(C)C(C1CCC1)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][CH2:12][CH2:14]1)=[O:10]

Participants

3

Reactant 2

HCID 15346381(2-Amino-5-methyl-phenyl)-cyclopropyl-methanoneHCID 45084194N-methoxy-N-methylcyclobutanecarboxamide

Product 1

HCID 66999162(2-Amino-5-methyl-phenyl)-cyclobutyl-methanoneYield 80%

Procedure

Crude (2-amino-5-methyl-phenyl)-cyclobutyl-methanone (80%, oil) was prepared in a similar fashion as described for (2-amino-5-methyl-phenyl)-cyclopropyl-methanone using cyclobutanecarboxylic acid methoxy-methyl-amide instead of cyclopropanecarboxylic acid methoxy-methyl-amide.

Sources & evidence

ORD record
ord-cafb6c79d28245dabbf92dda9cb423de
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

Loading…