N-methoxy-N-methylcyclohexanecarboxamide → (2-Amino-5-methyl-phenyl)-cyclohexyl-methanone

HRID 560033Notes

Reaction equation

HRID 560033 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][CH2:12]1)=[O:10].CON(C)[C:17]([CH:19]1CCCC[CH2:20]1)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][CH2:12][CH2:20][CH2:19][CH2:17]1)=[O:10]

Participants

3

Reactant 2

HCID 11769007N-methoxy-N-methylcyclohexanecarboxamideHCID 15346381(2-Amino-5-methyl-phenyl)-cyclopropyl-methanone

Product 1

HCID 66999196(2-Amino-5-methyl-phenyl)-cyclohexyl-methanoneYield 75%

Procedure

Crude (2-amino-5-methyl-phenyl)-cyclohexyl-methanone (75%, oil) was prepared in a similar fashion as described for (2-amino-5-methyl-phenyl)-cyclopropyl-methanone using cyclohexanecarboxylic acid methoxy-methyl-amide instead of cyclopropanecarboxylic acid methoxy-methyl-amide.

Sources & evidence

ORD record
ord-13dc93e595c34e578d8ced12d53f2d0d
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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