HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Carboxyphenylboronic acid | HCID 2733957 | — |
| Reactant | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one | HCID 67001148 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-3-carboxylic acid | HCID 44547740 | — |
Reaction Steps
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one (example 5, step 2) was reacted with 3-carboxyphenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-3-carboxylic acid as an off-white solid. MS: 497.2 ([M−H]−)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063088B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-5e180083da444c3cb8b18d74edfde66d |
| Source note | uspto-grants-2011_11 |