HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-Isopropyl-1-methanesulfonyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-Isopropyl-5-(3'-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one | HCID 67000948 | — |
| Product | 3-Isopropyl-1-methanesulfonyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one | HCID 44548045 | — |
Reaction Steps
In analogy to example 13, step 2,1-isopropyl-5-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one (example 13, step 1) was reacted with sodium hydride and methanesulfonyl chloride to give 3-isopropyl-1-methanesulfonyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one as an off-white solid. MS: 454.4 ([M+NH4]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063088B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-32162023c83048369065e615545a078f |
| Source note | uspto-grants-2011_11 |