反应详情

In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 5-(methylsulfonyl)-3-pyridineboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-3-isopropyl-4-[3-(5-methanesulfonyl-pyridin-3-yl)-phenyl]-imidazolidin-2-one as a light yellow oil. MS: 499.9 ([M+H]+)