HCID 66999834, compound → HCID 67000009, compound

Participants

Reaction Steps

A reaction flask equipped with a stir bar was charged with a solution of the above carboxylic acid (40 mg, 0.08 mmol) in methanol (10 mL). 10% Palladium on carbon (20 mg) was added. The reaction mixture was sealed with a rubber septum and the air was evacuated under house vacuum. A balloon filled with hydrogen gas was attached to the flask, and the reaction mixture was stirred for 5 h. The mixture was filtered through diatomaceous earth and the filtrate was evaporated. The residue was washed with 2 mL of ether and 2 mL of hexane. The product was dried and 5 mL of acetic acid was added. The acetic acid was evaporated under high vacuum to give the title compound as the acetate salt (25 mg, 71%).

Provenance & Evidence