HCID 59197938, compound → C-[1-(2-Oxa-6-aza-spiro[3.3]hept-6-yl)-cyclobutyl]-C-phenyl-methylamine

HRID 560217Notes

Reaction equation

HRID 560217 reaction equation
[CH2:1]1[C:4]2([CH2:7][N:6]([C:8]3([C:12]#[N:13])[CH2:11][CH2:10][CH2:9]3)[CH2:5]2)[CH2:3][O:2]1.[C:14]1([Li])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:1]1[C:4]2([CH2:7][N:6]([C:8]3([CH:12]([NH2:13])[C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH2:11][CH2:10][CH2:9]3)[CH2:5]2)[CH2:3][O:2]1

Participants

3

Reactant 2

HCID 59197938HCID 59197938, compoundHCID 178506676HCID 178506676, compound

Product 1

HCID 59197923C-[1-(2-Oxa-6-aza-spiro[3.3]hept-6-yl)-cyclobutyl]-C-phenyl-methylamine

Procedure

The title compound, yellow oil, MS: m/e=259.1 [(M+H)+], was prepared in accordance with the general method of intermediate B from 1-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-cyclobutanecarbonitrile (intermediate AF) and phenyllithium.

Sources & evidence

ORD record
ord-1232e580635841eda008bd70cf9a0a69
Source dataset
uspto-grants-2011_11
Patent number
US08063098B2

Reaction notes

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