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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 560227Generated: October 26, 2026

Thioacetamide → Methyl 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylate

https://huagongshe.com/reaction/560227

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThioacetamideHCID 2723949—
ReactantMethyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoateHCID 57437156—
ProductMethyl 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylateHCID 53271155—

Reaction Steps

prepared by reaction of 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. 1H-NMR (CDCl3): δ=2.75 (s, 3H); 3.84 (s, 3H); 7.10 (m, 2H); 7.47 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063099B2
Source datasetuspto-grants-2011_11
ORD IDord-1a1e7020f6d84377a381972ae88c8aae
Source noteuspto-grants-2011_11