Thiourea → methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate

HRID 560257Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:14])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:15][C:16]([NH2:18])=[S:17]>>[CH3:1][O:2][C:3]([C:4]1[N:15]=[C:16]([NH2:18])[S:17][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:14]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 11769817Methyl 3-chloro-2-oxo-3-phenylpropanoate

Product 1

HCID 664327methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate

Procedure

prepared by reaction of 3-chloro-2-oxo-3-phenyl-propionic acid methyl ester with thiourea. LC-MS: tR=0.77 min; [M+H]+=235.1.

Sources & evidence

ORD record: ord-6ba0722d9f564c839dfdf994c29333e0
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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