Dimethylamine → 2-Dimethylamino-5-phenyl-thiazole-4-carboxylic Acid

HRID 560262Notes

Reaction equation

HRID 560262 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7](Br)[S:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:4].[CH3:17][NH:18][CH3:19]>>[CH3:17][N:18]([CH3:19])[C:7]1[S:8][C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([C:3]([OH:2])=[O:4])[N:6]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 9814750Methyl 2-bromo-5-phenyl-1,3-thiazole-4-carboxylate

Product 1

HCID 668657152-Dimethylamino-5-phenyl-thiazole-4-carboxylic Acid

Procedure

prepared by reaction of 2-bromo-5-phenyl-thiazole-4-carboxylic acid methyl ester with dimethylamine. LC-MS: tR=0.81 min; [M+H]+=249.1.

Sources & evidence

ORD record
ord-88641bd2ff4a4878895b7509e72f04e2
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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