反应详情

A mixture of 5-(3-fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid ethyl ester (0.56 mmol), EtOH (0.63 mL) and aq. NaOH solution (2.0 M, 0.63 mL) is stirred for 2 h at RT and washed once with ether. The aq. layer is made acidic by addition of conc HCl and extracted twice with ether. The combined organic layers are dried over MgSO4 and concentrated in vacuo to give the desired acid as a pure yellow solid. LC-MS (basic): tR=0.49 min; [M−H]−=220.3.

1. washwashed once with ether
2. additionThe aq. layer is made acidic by addition of conc HCl
3. extractionextracted twice with ether
4. dry with materialThe combined organic layers are dried over MgSO4
5. concentrationconcentrated in vacuo