Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate → 3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

HRID 560279Notes

Reaction equation

HRID 560279 reaction equation
C[O:2][C:3]([C:5]1[C:14]2[O:13][CH2:12][C:11](=[O:15])[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4]>CC#N>[O:15]=[C:11]1[NH:10][C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[C:14]=2[O:13][CH2:12]1

Participants

3

Reactant 1

HCID 23770643Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate

Product 1

HCID 183549413-Oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

prepared by saponification of 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester. LC-MS: tR=0.56 min; [M+CH3CN+H]+=235.0.

Sources & evidence

ORD record
ord-1313ecd0d47b46e08132f83b6a7ed2a4
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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