6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloro-imidazo[2,1-b]thiazole-5-carboxylic acid

Participants

Reaction Steps

A solution of sodium chlorite (230 mmol) and sodium dihydrogen phosphate dihydrate (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid.

Provenance & Evidence