Sodium Hydroxide → HCID 58807846, compound

Participants

Reaction Steps

At 0° C. a solution of (1aS,1bS,4R,5aR)-4-Phenyl-tetrahydro-3-oxa-4a-aza-cyclopropa[a]pentalen-5-one (13.9 mmol) in THF (15 mL) is added dropwise to a suspension of lithium aluminum hydride (20.9 mmol) in THF (14 mL) and the mixture is stirred at reflux for 1 h. After cooling to 0° C. water (0.80 mL), aq. NaOH solution (15%, 0.80 mL), THF (15 mL) and additional water (2.0 mL) are added with caution and the mixture is stirred vigorously for 2 h. Na2SO4 is added, the suspension is filtered through celite and the solvents are removed in vacuo to give the desired product. LC-MS (basic): tR=0.84 min; [M+H]+=204.4.

Provenance & Evidence