Imidazo(1,2-a)pyridine-3-carboxylic acid → (1S,2S,5R)-2-{[(Imidazo[1,2-a]pyridine-3-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

HRID 560342Notes

Reaction equation

HRID 560342 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:16]1[CH:17]=[C:18]([C:25](O)=[O:26])[N:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=12>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH:15][C:25]([C:18]1[N:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]2=[N:16][CH:17]=1)=[O:26])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 73142Imidazo(1,2-a)pyridine-3-carboxylic acidHCID 59444330tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylate

Product 1

HCID 66997967(1S,2S,5R)-2-{[(Imidazo[1,2-a]pyridine-3-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

Procedure

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with Imidazo[1,2-a]pyridine-3-carboxylic acid.

Sources & evidence

ORD record
ord-f82f9806fa5f45018e8a8e69b1fe1290
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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