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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 560343Generated: October 26, 2026

2,3-Dihydro-1-benzofuran-4-carboxylic acid → (1S,2S,5R)-2-{[(2,3-Dihydro-benzofuran-4-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

https://huagongshe.com/reaction/560343

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-Dihydro-1-benzofuran-4-carboxylic acidHCID 18787444—
Reactanttert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylateHCID 59444330—
Product(1S,2S,5R)-2-{[(2,3-Dihydro-benzofuran-4-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl EsterHCID 66998733—

Reaction Steps

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 2,3-Dihydro-benzofuran-4-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063099B2
Source datasetuspto-grants-2011_11
ORD IDord-e1b9afccf36f40f09c19f6f97901a2ad
Source noteuspto-grants-2011_11