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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 560348Generated: October 28, 2026

2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid → 2,2,2-Trifluoro-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-acetamide

https://huagongshe.com/reaction/560348

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-m-tolyl-thiazole-4-carboxylic acidHCID 53271816—
ReactantN-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamideHCID 59444331—
Product2,2,2-Trifluoro-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-acetamideHCID 86644206—

Reaction Steps

prepared by reaction of N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide with 2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063099B2
Source datasetuspto-grants-2011_11
ORD IDord-e3c4ea5cf4a14184989c6db13ffb8655
Source noteuspto-grants-2011_11