5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid → N-{(1S,2S,5R)-3-[5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-2,2,2-trifluoro-acetamide

Participants

Role	Name	HCID	Charge
Reactant	5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid	HCID 53271192	—
Reactant	N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide	HCID 59444331	—
Product	N-{(1S,2S,5R)-3-[5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-2,2,2-trifluoro-acetamide	HCID 86644207	—

Reaction Steps

prepared by reaction of N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide with 5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid. LC-MS (basic): tR=0.92 min; [M+H]+=444.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-a240b19bdf264af0943bc3702a8b3572
Source note	uspto-grants-2011_11