2-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acid → N-{(1S,2S,5R)-3-[2-Amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-2,2,2-trifluoro-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acid	HCID 57437179	—
Reactant	N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide	HCID 59444331	—
Product	N-{(1S,2S,5R)-3-[2-Amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-2,2,2-trifluoro-acetamide	HCID 86644208	—

Reaction Steps

prepared by reaction of N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide with 2-Amino-5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid. LC-MS (basic): tR=0.80 min; [M+H]+=429.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-14b606bfb20547bdba5a627b289cb35c
Source note	uspto-grants-2011_11