o-Phenylbenzoic acid → Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(biphenyl-2-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560356Notes

Reaction equation

HRID 560356 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10].[C:20]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:21]([C:26](O)=[O:27])=[CH:22][CH:23]=[CH:24][CH:25]=1>>[C:20]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:21]([C:26]([N:3]2[CH2:4][C@H:5]3[C@H:1]([CH2:6]3)[C@H:2]2[CH2:7][NH:8][C:9]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[O:19][CH:18]=[CH:17][C:16]=23)=[O:10])=[O:27])=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 70357o-Phenylbenzoic acidHCID 66998521Benzofuran-4-carboxylic acid[(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 25182532Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(biphenyl-2-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of benzofuran-4-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with biphenyl-2-carboxylic acid.

Sources & evidence

ORD record
ord-ad2b1499cf6c4bcbb8b36e83ead9504a
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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