2-Methoxybenzoic acid → Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(2-methoxy-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560358Notes

Reaction equation

HRID 560358 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10].[CH3:20][O:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](O)=[O:25]>>[CH3:20][O:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10])=[O:25]

Participants

3

Reactant 2

HCID 113702-Methoxybenzoic acidHCID 66998521Benzofuran-4-carboxylic acid[(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 66998646Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(2-methoxy-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of benzofuran-4-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 2-methoxy-benzoic acid.

Sources & evidence

ORD record
ord-f290aeaaf8254794a9a24e662ecb0bc2
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

Loading…