5-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → HCID 25182398, compound

HRID 560363Notes

Reaction equation

HRID 560363 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10].[F:20][C:21]1[CH:22]=[C:23]([C:27]2[S:31][C:30]([CH3:32])=[N:29][C:28]=2[C:33](O)=[O:34])[CH:24]=[CH:25][CH:26]=1>>[F:20][C:21]1[CH:22]=[C:23]([C:27]2[S:31][C:30]([CH3:32])=[N:29][C:28]=2[C:33]([N:3]2[CH2:4][C@H:5]3[C@H:1]([CH2:6]3)[C@H:2]2[CH2:7][NH:8][C:9]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[O:19][CH:18]=[CH:17][C:16]=23)=[O:10])=[O:34])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 574371745-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 66998521Benzofuran-4-carboxylic acid[(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 25182398HCID 25182398, compound

Procedure

prepared by reaction of Benzofuran-4-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 5-(3-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid. LC-MS (basic): tR=0.90 min; [M+H]+=476.0.

Sources & evidence

ORD record
ord-b2173bcc9e1c4daca796ebbc8ab1ecab
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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