5-(2-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{(1s,2s,5r)-3-[5-(2-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

HRID 560364Notes

Reaction equation

HRID 560364 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10].[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[S:31][C:30]([CH3:32])=[N:29][C:28]=1[C:33](O)=[O:34]>>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[S:31][C:30]([CH3:32])=[N:29][C:28]=1[C:33]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10])=[O:34]

Participants

3

Reactant 2

HCID 521245675-(2-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 669978466-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 251832806-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{(1s,2s,5r)-3-[5-(2-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

Procedure

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-86190ac64ace4b46a0ae300976200e4d
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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