3-Bromothiophene-2-carboxylic acid → HCID 66998709, compound

HRID 560381Notes

Reaction equation

HRID 560381 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10].[Br:20][C:21]1[CH:25]=[CH:24][S:23][C:22]=1[C:26](O)=[O:27]>>[Br:20][C:21]1[CH:25]=[CH:24][S:23][C:22]=1[C:26]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10])=[O:27]

Participants

3

Reactant 2

HCID 27396883-Bromothiophene-2-carboxylic acidHCID 669978466-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 66998709HCID 66998709, compound

Procedure

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 3-Bromo-thiophene-2-carboxylic acid. LC-MS (basic): tR=1.22 min; [M+H]+=465.0.

Sources & evidence

ORD record
ord-be9fd6db484a4547ae0efe76108b8d25
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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