2-(Thiophen-2-yl)benzoic acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1s,2s,5r)-3-(2-thiophen-2-yl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560386Notes

Reaction equation

HRID 560386 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10].[S:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]1[CH:33]=[CH:32][CH:31]=[CH:30][C:26]=1[C:27](O)=[O:28]>>[S:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]1[CH:33]=[CH:32][CH:31]=[CH:30][C:26]=1[C:27]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10])=[O:28]

Participants

3

Reactant 2

HCID 51056232-(Thiophen-2-yl)benzoic acidHCID 669978466-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 251835716-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1s,2s,5r)-3-(2-thiophen-2-yl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 2-Thiophen-2-yl-benzoic acid. LC-MS (basic): tR=1.33 min; [M+H]+=463.1.

Sources & evidence

ORD record
ord-f2ab330bc5264cf9afcc36a72bbd134c
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

Loading…