5-Methyl-2-p-tolyl-2H-pyrazole-3-carboxylic acid → HCID 66998931, compound

HRID 560387Notes

Reaction equation

HRID 560387 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10].[CH3:20][C:21]1[CH:22]=[C:23]([C:33](O)=[O:34])[N:24]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[N:25]=1>>[CH3:20][C:21]1[CH:22]=[C:23]([C:33]([N:3]2[CH2:4][C@H:5]3[C@H:1]([CH2:6]3)[C@H:2]2[CH2:7][NH:8][C:9]([C:11]2[N:18]3[C:14]([S:15][CH:16]=[CH:17]3)=[N:13][C:12]=2[CH3:19])=[O:10])=[O:34])[N:24]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[N:25]=1

Participants

3

Reactant 2

HCID 27695945-Methyl-2-p-tolyl-2H-pyrazole-3-carboxylic acidHCID 669978466-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 66998931HCID 66998931, compound

Procedure

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 5-Methyl-2-p-tolyl-2H-pyrazole-3-carboxylic acid. LC-MS (basic): tR=1.27 min; [M+H]+=475.2.

Sources & evidence

ORD record
ord-e478f9398d384b19ab9cd0c1d821dfdf
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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