6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide → HCID 25183717, compound

HRID 560391Notes

Reaction equation

HRID 560391 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[N:18]2[C:14]([S:15][CH:16]=[CH:17]2)=[N:13][C:12]=1[CH3:19])=[O:10].[F:20][C:21]1[CH:22]=[C:23]([C:27]2[N:28]=[C:29]([CH3:35])[S:30][C:31]=2[C:32](O)=[O:33])[CH:24]=[CH:25][CH:26]=1>>[F:20][C:21]1[CH:22]=[C:23]([C:27]2[N:28]=[C:29]([CH3:35])[S:30][C:31]=2[C:32]([N:3]2[CH2:4][C@H:5]3[C@H:1]([CH2:6]3)[C@H:2]2[CH2:7][NH:8][C:9]([C:11]2[N:18]3[C:14]([S:15][CH:16]=[CH:17]3)=[N:13][C:12]=2[CH3:19])=[O:10])=[O:33])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 669978466-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amideHCID 66998173HCID 66998173, compound

Product 1

HCID 25183717HCID 25183717, compound

Procedure

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic Acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 4-(3-Fluoro-phenyl)-2-methyl-thiazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-409f7b3f22994c4f98d096bee2ef6d5e
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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