2,3-Dihydrothieno(3,4-b)(1,4)dioxine-5-carboxylic acid → 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydrothieno(3,4-b)(1,4)dioxine-5-carboxylic acid	HCID 6483880	—
Reactant	((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone	HCID 66998654	—
Product	2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide	HCID 25182676	—

Reaction Steps

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.85 min; [M+H]+=496.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-119e102c090f4441891ac53cd9eb84e2
Source note	uspto-grants-2011_11