反应详情

To 15.50 g of N-hydroxymethyl-2-(trifluoromethyl)benzamide in 200 ml of dichloromethane, 16.83 g of thionyl chloride was added dropwise with stirring under cooling with ice, and after the addition, the mixture was stirred at room temperature for another 3 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the precipitated solid was washed with 50 ml of hexane to obtain 16.90 g of the desired product as white crystals.

1. temperatureunder cooling with ice
2. additionafter the addition
3. stirringthe mixture was stirred at room temperature for another 3 hours
4. customAfter completion of the reaction
5. customthe solvent was evaporated under reduced pressure
6. washthe precipitated solid was washed with 50 ml of hexane