2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid → 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid	HCID 78184	—
Reactant	((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone	HCID 66998493	—
Product	2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide	HCID 25181851	—

Reaction Steps

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.89 min; [M+H]+=510.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-3d11973515644f1cb267e0ef9c1b2ea8
Source note	uspto-grants-2011_11