2,3-Dihydrothieno(3,4-b)(1,4)dioxine-5-carboxylic acid → 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydrothieno(3,4-b)(1,4)dioxine-5-carboxylic acid	HCID 6483880	—
Reactant	((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone	HCID 66998493	—
Product	2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide	HCID 25182524	—

Reaction Steps

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.86 min; [M+H]+=516.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-4fb329904230464fb87f58644f64acee
Source note	uspto-grants-2011_11