2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid → 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid	HCID 78184	—
Reactant	[2-Amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,2S,5R)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone	HCID 86644211	—
Product	2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid{(1s,2s,5r)-3-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide	HCID 25182528	—

Reaction Steps

prepared by reaction of [2-Amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,2S,5R)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone with 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.77 min; [M+H]+=495.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063099B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-d526a180c5fc4f4c8737ada31dcf332f
Source note	uspto-grants-2011_11